Hi gfoxjr,
This is certainly possible, but will require some basic customization on your end. From the Sales Order List Screen, you'll need to add a new Grid View to the Sales Order Grid which has the Criteria 'SalesOrder.IsFullyInvoiced = No AND SalesOrder.IsManuallyClosed = no'.
Let me know if you need a little more detail to set this one up and Ill be happy to help out!
-Ben