Hi Bryan,
Unfortunately, at this time we don't offer native support for Office 365 -- it's in development. The only thing I can think of is that some versions of Office 365 may offer you the ability to use a Desktp client with it, in which case the plugin may work, but otherwise there's no real way to integrate it unfortunately.
I'm assuming you meant the Outlook Plugin btw -- or did you just want ot reconfigure your SMTP? Did you get a new email address/server?
Naeem